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Compritol 888 ATO is a waterinsoluble excipient it does not swell or erode in contact with the aqueous medium When used as an SR agent in tablet it forms an inert matrix through which the drug diffuses out slowly The matrix geometrytablet size does not change throughout dissolution Therefore it is
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Tablet thickness surface area volume and surface area to volume ra tio values for 12 mm tablets produced at di erent compression for ces and speeds mean SD n 10 A 12 kN 20 kN 30 kN
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Graph 3 Diclofenac sodiumCompritol 888 ATO tablets produced by DCS Performance of a Compritol 888 ATO Lipid Matrix Tablet to Deliver Sustained Release of Diclofenac Sodium D Marchaud E DauphinChanard JM Girard and C Miolane GattEfossé 36 chemin de Genas BP 603 f69804 saint Priest Cedex fRaNCE dmarchaudgattefossecom
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